Massive levothyroxine ingestion.
نویسندگان
چکیده
Cavitary lesions due to pulmonary tuberculosis are very rare in infants, although these may be found in older children and adolescents [1]. We report a six-month-old girl who presented with history of recurrent episodes of respiratory infections, failure to gain weight, rapid respiration and feeding difficulty since 3 months of age. Failure to thrive, respiratory distress, clubbing and decreased air entry in right infra mammary region with coarse crepitations were evident on clinical examination. Full Blood count revealed anemia and neutrophilic leucocytosis. Chest X-ray revealed a large cystic lesion in right middle and lower zone (Fig. 1). With provisional diagnosis of Congenital cystic adenomatous malformation (CCAM)/congenital lobar emphysema (CLE) with consolidation/staphyolococcal pneumatocele, antibiotics and supportive treatment were initiated. On High resolution computerised tomography of thorax, CCAM/CLE were ruled out, and features of pneumatocele with endobronchial obstruction of bronchi with mucus plugs on right side were found. Bronchoscopy revealed granulation tissue in the bifurcation of right main bronchus, distal end of right middle lobe bronchus and right lower lobe bronchus. Mother had history of chronic cough and intermittent fever of 5 months duration for which she had received antibiotics and bronchodilators. Her chest X-ray revealed similar cavitary lesion in the lower zone of right lung. Acid-fast-bacilli were found in her sputum. Both infant and mother were put on anti-tuberculosis treatment, and on six month follow up child had gained 3 Kg weight. Her symptoms had disappeared with radiological clearance of lesion. We emphasize to consider tuberculosis in any infant presenting with chronic respiratory symptoms with failure to thrive. Cavitary lesion in lung is a rare presentation of tuberculosis in infants. Contact tracing is crucial in arriving at diagnosis for early treatment and good outcome.
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and hypertension. Annual report of the American Association of Poison Control Centers' National Poison Data System of 2008 revealed that out of 9,006 unique exposures to thyroid preparations only 3 cases had major adverse outcome and there were no deaths[4]. It has been documented that there is no correlation between the amount of levothyroxine ingested and the onset and severity of the symptom...
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BACKGROUND Levothyroxine (l-thyroxine) intoxication may arise from intentional or accidental ingestion of excessive doses of the hormone and may cause symptoms equivalent to thyroid storm. We report a case of massive accidental l-thyroxine intoxication resulting from an error in the preparation of capsules to treat goiter. SUMMARY A 61-year-old woman was admitted showing high levels of thyroi...
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Acute ingestion of thyroid hormone preparations is a common intoxication, with 181 cases in children <12 yr in 2009 in the Netherlands, but generally has a mild course. However, some reports show that even low dosages may cause serious events such as seizures, thyroid storm and coma. We report a 3 yr old boy case with an acute intoxication with high dose levothyroxine (0.5 mg/kg). We describe t...
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متن کاملTable I Serial Thyroid Function Tests after Levothyroxine Ingestion
136/min). ECG showed sinus tachycardia. The total T3 and T4 levels were elevated: levels of thyroid stimulating hormone were low (Table I). Child was started on propranolol 1 mg/kg/day. Tachycardia settled 7 days after propranolol was started and the drug was subsequently stopped. The serial fT3, fT4 and TSH levels are summarized in Table I. The younger sibling was symptomfree at presentation a...
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ورودعنوان ژورنال:
- Indian pediatrics
دوره 51 10 شماره
صفحات -
تاریخ انتشار 2014